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Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
Shimizu, Takahiro; Takahashi, Norihito; Huber, Vincent J; Asawa, Yasunobu; Ueda, Hiroki; Yoshimori, Atsushi; Muramatsu, Yukiko; Seimiya, Hiroyuki; Kouji, Hiroyuki; Nakamura, Hiroyuki; Oguri, Hiroki.
Affiliation
  • Shimizu T; Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
  • Takahashi N; Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
  • Huber VJ; Oita University Institute of Advanced Medicine, Inc., 17-20 Higashi kasuga-machi, Oita-shi, Oita 870-0037, Japan.
  • Asawa Y; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.
  • Ueda H; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.
  • Yoshimori A; Institute for Theoretical Medicine, Inc., 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Muramatsu Y; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
  • Seimiya H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
  • Kouji H; Oita University Institute of Advanced Medicine, Inc., 17-20 Higashi kasuga-machi, Oita-shi, Oita 870-0037, Japan.
  • Nakamura H; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.
  • Oguri H; Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: hirokioguri@g.ecc.u-tokyo.ac.jp.
Bioorg Med Chem ; 30: 115949, 2021 01 15.
Article in En | MEDLINE | ID: mdl-33360196
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Macrocyclic Compounds / Alkaloids / Hypoxia-Inducible Factor 1, alpha Subunit / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Macrocyclic Compounds / Alkaloids / Hypoxia-Inducible Factor 1, alpha Subunit / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Affiliation country: Japón Country of publication: Reino Unido