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Ablating Adult Neural Stem Cells Improves Synaptic and Cognitive Functions in Alzheimer Models.
Zhang, Xiaoqin; Mei, Yufei; He, Yang; Wang, Dongpi; Wang, Jing; Wei, Xiaojie; Yang, Enlu; Zhou, Dongming; Shen, Haowei; Peng, Guoping; Shu, Qiang; Li, Xuekun; Luo, Benyan; Zhou, Yudong; Sun, Binggui.
Affiliation
  • Zhang X; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; Department of Physiology and Pharmacology, Medical School of Ningbo University, Ningbo, Zhejiang Province, 315211, China.
  • Mei Y; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • He Y; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • Wang D; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310052, China.
  • Wang J; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • Wei X; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • Yang E; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • Zhou D; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310052, China.
  • Shen H; Department of Physiology and Pharmacology, Medical School of Ningbo University, Ningbo, Zhejiang Province, 315211, China.
  • Peng G; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China.
  • Shu Q; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310052, China.
  • Li X; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310052, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310029, China.
  • Luo B; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China.
  • Zhou Y; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
  • Sun B; Department of Neurobiology and Department of Neurology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou,
Stem Cell Reports ; 16(1): 89-105, 2021 01 12.
Article in En | MEDLINE | ID: mdl-33382977
ABSTRACT
Adult neurogenesis is impaired in the hippocampus of patients with Alzheimer disease (AD) as well as AD models. However, it is far from clear how modulating adult neurogenesis affects AD neuropathology. We confirm that adult hippocampal neurogenesis is impaired in two AD models. Surprisingly, however, cognitive functions are improved in AD models after ablating adult neural stem cells (aNSCs). Ablation of aNSCs does not affect the levels of amyloid ß but restores the normal synaptic transmission in the dentate gyrus (DG) granule cells of AD models. Furthermore, calbindin depletion in the DG of AD mice is ameliorated after aNSC ablation, and knocking down calbindin abolishes the effects of aNSC ablation on synaptic and cognitive functions of AD mice. Together, our data suggest that cognitive functions of AD mice are improved after aNSC ablation, which is associated with the restoration of synaptic transmission in the DG granule cells with calbindin as an important mediator.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognition / Synaptic Transmission / Neural Stem Cells / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognition / Synaptic Transmission / Neural Stem Cells / Alzheimer Disease Limits: Animals / Humans Language: En Journal: Stem Cell Reports Year: 2021 Document type: Article Affiliation country: China