A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review.
Mini Rev Med Chem
; 21(13): 1770-1795, 2021.
Article
in En
| MEDLINE
| ID: mdl-33397258
ABSTRACT
A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Design
/
Pyrazolones
Limits:
Humans
Language:
En
Journal:
Mini Rev Med Chem
Journal subject:
QUIMICA
Year:
2021
Document type:
Article
Affiliation country:
India