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Toxoplasma gondii infection and the risk of adult glioma in two prospective studies.
Hodge, James M; Coghill, Anna E; Kim, Youngchul; Bender, Noemi; Smith-Warner, Stephanie A; Gapstur, Susan; Teras, Lauren R; Grimsrud, Tom K; Waterboer, Tim; Egan, Kathleen M.
Affiliation
  • Hodge JM; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA.
  • Coghill AE; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
  • Kim Y; Department of Biostatistics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
  • Bender N; Infections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
  • Smith-Warner SA; Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Gapstur S; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA.
  • Teras LR; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA.
  • Grimsrud TK; Department of Research, Cancer Registry of Norway, Oslo, Norway.
  • Waterboer T; Infections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
  • Egan KM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Int J Cancer ; 148(10): 2449-2456, 2021 May 15.
Article in En | MEDLINE | ID: mdl-33427315
ABSTRACT
Toxoplasma gondii (T gondii) is a common parasite that shows affinity to neural tissue and may lead to the formation of cysts in the brain. Previous epidemiologic studies have suggested an association between glioma and increased prevalence of T gondii infection, but prospective studies are lacking. Therefore, we examined the association between prediagnostic T gondii antibodies and risk of glioma in two prospective cohorts using a nested case-control study design. Cases and matched controls were selected from the American Cancer Society's Cancer Prevention Study-II Nutrition Cohort (CPSII-NC) (n = 37 cases and 74 controls) and the Norwegian Cancer Registry's Janus Serum Bank (Janus) (n = 323 cases and 323 controls). Blood samples collected prior to diagnosis were analyzed for antibodies to two T gondii surface antigens (p22 and sag-1), with individuals considered seropositive if antibodies to either antigen were detected. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95% CI) for each cohort. In both cohorts, a suggestive increase in glioma risk was observed among those infected with T gondii (OR 2.70; 95% CI 0.96-7.62 for CPSII-NC; OR 1.32, 95% CI 0.85-2.07 for Janus), particularly among participants with high antibody titers specific to the sag-1 antigen (CPSII-NC OR 3.35, 95% CI 0.99-11.38; Janus OR 1.79, 95% CI 1.02-3.14). Our findings provide the first prospective evidence of an association between T gondii infection and risk of glioma. Further studies with larger case numbers are needed to confirm a potential etiologic role for T gondii in glioma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: Int J Cancer Year: 2021 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: Int J Cancer Year: 2021 Document type: Article Affiliation country: Estados Unidos