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Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
Oki, Toshihiko; Mercier, Francois; Kato, Hiroki; Jung, Yookyung; McDonald, Thomas O; Spencer, Joel A; Mazzola, Michael C; van Gastel, Nick; Lin, Charles P; Michor, Franziska; Kitamura, Toshio; Scadden, David T.
Affiliation
  • Oki T; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Mercier F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Kato H; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.
  • Jung Y; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • McDonald TO; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Spencer JA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.
  • Mazzola MC; McGill University, Montreal, QC, H3A 0G4, Canada.
  • van Gastel N; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Lin CP; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
  • Michor F; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.
  • Kitamura T; Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Scadden DT; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
Nat Commun ; 12(1): 245, 2021 01 11.
Article in En | MEDLINE | ID: mdl-33431855
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Mechanistic Target of Rapamycin Complex 1 Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Mechanistic Target of Rapamycin Complex 1 Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido