Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase.
Ocul Oncol Pathol
; 6(6): 416-421, 2020 Dec.
Article
in En
| MEDLINE
| ID: mdl-33447591
ABSTRACT
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Ocul Oncol Pathol
Year:
2020
Document type:
Article
Affiliation country:
Australia