Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila.
Exp Cell Res
; 399(2): 112486, 2021 02 15.
Article
in En
| MEDLINE
| ID: mdl-33450208
ABSTRACT
Dynamic changes in mitochondrial shape and size are vital for mitochondrial health and for tissue development and function. Adult Drosophila indirect flight muscles contain densely packed mitochondria. We show here that mitochondrial fusion is critical during early muscle development (in pupa) and that silencing of the outer mitochondrial membrane fusion gene, Marf, in muscles results in smaller mitochondria that are functionally defective. This leads to abnormal muscle development resulting in muscle dysfunction in adult flies. However, post-developmental silencing of Marf has no obvious effects on mitochondrial and muscle phenotype in adult flies, indicating the importance of mitochondrial fusion during early muscle development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drosophila Proteins
/
Muscle Development
/
Drosophila melanogaster
/
Mitochondrial Dynamics
/
Flight, Animal
/
Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Exp Cell Res
Year:
2021
Document type:
Article