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A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
Barghout, Samir H; Aman, Ahmed; Nouri, Kazem; Blatman, Zachary; Arevalo, Karen; Thomas, Geethu E; MacLean, Neil; Hurren, Rose; Ketela, Troy; Saini, Mehakpreet; Abohawya, Moustafa; Kiyota, Taira; Al-Awar, Rima; Schimmer, Aaron D.
Affiliation
  • Barghout SH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Aman A; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Nouri K; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
  • Blatman Z; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Arevalo K; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Thomas GE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • MacLean N; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Hurren R; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Ketela T; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Saini M; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Abohawya M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Kiyota T; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Al-Awar R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Schimmer AD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
JCI Insight ; 6(5)2021 03 08.
Article in En | MEDLINE | ID: mdl-33476303
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Repressor Proteins / Sulfides / Sulfonamides / Leukemia, Myeloid, Acute / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Enzyme Inhibitors / ATP Binding Cassette Transporter, Subfamily G, Member 2 Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: JCI Insight Year: 2021 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Repressor Proteins / Sulfides / Sulfonamides / Leukemia, Myeloid, Acute / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Enzyme Inhibitors / ATP Binding Cassette Transporter, Subfamily G, Member 2 Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: JCI Insight Year: 2021 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos