Murine Myeloid Progenitors Attenuate Immune Dysfunction Induced by Hemorrhagic Shock.
Stem Cell Reports
; 16(2): 324-336, 2021 02 09.
Article
in En
| MEDLINE
| ID: mdl-33482101
ABSTRACT
Hemorrhagic shock induces an aberrant immune response characterized by simultaneous induction of a proinflammatory state and impaired host defenses. The objective of this study was to evaluate the impact of conditionally immortalized neutrophil progenitors (NPs) on this aberrant immune response. We employed a mouse model of hemorrhagic shock, followed by the adoptive transfer of NPs and subsequent inoculation of Staphylococcus aureus to induce pneumonia. We observed that transplant of NPs decreases the proportion of host neutrophils that express programmed death ligand 1 and intercellular adhesion molecule 1 in the context of prior hemorrhage. Following hemorrhage, NP transplant decreased proinflammatory cytokines in the lungs, increased neutrophil migration into the airspaces, and enhanced bacterial clearance. Further, hemorrhagic shock improved NP engraftment in the bone marrow. These results suggest that NPs hold the potential for use as a cellular therapy in the treatment and prevention of secondary infection following hemorrhagic shock.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia
/
Shock, Hemorrhagic
/
Staphylococcus aureus
/
Myeloid Progenitor Cells
/
Neutrophils
Limits:
Animals
Language:
En
Journal:
Stem Cell Reports
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos