Electrogenerated NHCs in Organic Synthesis: Ionic Liquids vs Organic Solvents Effects.
Chem Rec
; 21(9): 2130-2147, 2021 Sep.
Article
in En
| MEDLINE
| ID: mdl-33507627
ABSTRACT
In the last twenty years, N-heterocyclic carbenes (NHCs) have been extensively studied for their application as organocatalysts in stereoselective synthesis as well as ligands for transition metals-promoted synthetic methodologies. Derived mainly from azolium salts, NHCs have demonstrated exceptional versatility in their generation usually performed by deprotonation or reduction (chemical or electrochemical). In particular, the generation of NHC under electrochemical conditions, starting from azolium-based ionic liquids, has proven to be a successful green approach and demonstrated wide applicability in organic synthesis. In this Personal Account, the application of electrogenerated NHCs in organic synthesis will be discussed, with a particular attention to the different reactivity in ionic liquids compared to classical organic solvents.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Rec
Journal subject:
QUIMICA
Year:
2021
Document type:
Article
Affiliation country:
Italia