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Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex.
Jonsson, William O; Margolies, Nicholas S; Mirek, Emily T; Zhang, Qian; Linden, Melissa A; Hill, Cristal M; Link, Christopher; Bithi, Nazmin; Zalma, Brian; Levy, Jordan L; Pettit, Ashley P; Miller, Joshua W; Hine, Christopher; Morrison, Christopher D; Gettys, Thomas W; Miller, Benjamin F; Hamilton, Karyn L; Wek, Ronald C; Anthony, Tracy G.
Affiliation
  • Jonsson WO; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Margolies NS; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Mirek ET; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Zhang Q; Department of Health and Exercise Science, Colorado State University, Ft. Collins, CO, USA.
  • Linden MA; Department of Health and Exercise Science, Colorado State University, Ft. Collins, CO, USA.
  • Hill CM; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Link C; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Bithi N; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
  • Zalma B; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
  • Levy JL; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Pettit AP; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Miller JW; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Hine C; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
  • Morrison CD; Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
  • Gettys TW; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Miller BF; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Hamilton KL; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Wek RC; Department of Health and Exercise Science, Colorado State University, Ft. Collins, CO, USA.
  • Anthony TG; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
J Nutr ; 151(4): 785-799, 2021 04 08.
Article in En | MEDLINE | ID: mdl-33512502
ABSTRACT

BACKGROUND:

Dietary sulfur amino acid restriction (SAAR) improves body composition and metabolic health across several model organisms in part through induction of the integrated stress response (ISR).

OBJECTIVE:

We investigate the hypothesis that activating transcription factor 4 (ATF4) acts as a converging point in the ISR during SAAR.

METHODS:

Using liver-specific or global gene ablation strategies, in both female and male mice, we address the role of ATF4 during dietary SAAR.

RESULTS:

We show that ATF4 is dispensable in the chronic induction of the hepatokine fibroblast growth factor 21 while being essential for the sustained production of endogenous hydrogen sulfide. We also affirm that biological sex, independent of ATF4 status, is a determinant of the response to dietary SAAR.

CONCLUSIONS:

Our results suggest that auxiliary components of the ISR, which are independent of ATF4, are critical for SAAR-mediated improvements in metabolic health in mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Activating Transcription Factor 4 / Amino Acids, Sulfur Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Nutr Year: 2021 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Activating Transcription Factor 4 / Amino Acids, Sulfur Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Nutr Year: 2021 Document type: Article Affiliation country: Estados Unidos