Selinexor, a First in Class, Nuclear Export Inhibitor for the Treatment of Advanced Malignant Peripheral Nerve Sheath Tumor.
Oncologist
; 26(4): e710-e714, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-33512749
ABSTRACT
Malignant peripheral nerve sheath tumor (MPNST) is a highly malignant neoplasm arising from peripheral nerve or its attendant sheath and is derived from Schwann or pluripotent cells of neural crest origin. Patients with recurrent, unresectable, or advanced stage disease have limited treatment options, and current therapies are associated with little benefit. In this article, we report nine cases of MPNST treated with selinexor, an orally bioavailable, selective inhibitor of nuclear export, accompanied by tumor stabilization or regression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurofibrosarcoma
/
Nerve Sheath Neoplasms
Limits:
Humans
Language:
En
Journal:
Oncologist
Journal subject:
NEOPLASIAS
Year:
2021
Document type:
Article
Affiliation country:
Canadá