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Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Vasquez, Guillermo; Freestone, Graeme C; Wan, W Brad; Low, Audrey; De Hoyos, Cheryl Li; Yu, Jinghua; Prakash, Thazha P; Ǿstergaard, Michael E; Liang, Xue-Hai; Crooke, Stanley T; Swayze, Eric E; Migawa, Michael T; Seth, Punit P.
Affiliation
  • Vasquez G; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Freestone GC; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Wan WB; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Low A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • De Hoyos CL; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Yu J; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Prakash TP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Ǿstergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Liang XH; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Crooke ST; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Migawa MT; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Nucleic Acids Res ; 49(4): 1828-1839, 2021 02 26.
Article in En | MEDLINE | ID: mdl-33544849
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Oligonucleotides, Antisense Limits: Animals / Humans / Male Language: En Journal: Nucleic Acids Res Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Oligonucleotides, Antisense Limits: Animals / Humans / Male Language: En Journal: Nucleic Acids Res Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido