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New Advanced Glycation End Products Observed in Rat Urine by Untargeted Metabolomics after Feeding with Heat-Treated Skimmed Milk Powder.
Zhou, Xiaomin; Ulaszewska, Maria M; De Gobba, Cristian; Rinnan, Åsmund; Poulsen, Malene W; Chen, Jie; Mattivi, Fulvio; Hedegaard, Rikke Vingborg; Skibsted, Leif Horsfelt; Dragsted, Lars Ove.
Affiliation
  • Zhou X; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, 1958, Denmark.
  • Ulaszewska MM; Department of Food Quality and Nutrition, Fondazione Edmund Mach, Research and Innovation Centre, San Michele all'Adige, Italy.
  • De Gobba C; Center for Omics Sciences, Proteomics and Metabolomics Facility - ProMeFa, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Rinnan Å; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, 1958, Denmark.
  • Poulsen MW; Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, 1958, Denmark.
  • Chen J; Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg, 1958, Denmark.
  • Mattivi F; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, 1958, Denmark.
  • Hedegaard RV; State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
  • Skibsted LH; Department of Food Quality and Nutrition, Fondazione Edmund Mach, Research and Innovation Centre, San Michele all'Adige, Italy.
  • Dragsted LO; Department of Cellular, Computational, and Integrative Biology - CIBIO, University of Trento, Trento, Italy.
Mol Nutr Food Res ; 65(7): e2001049, 2021 04.
Article in En | MEDLINE | ID: mdl-33559951
ABSTRACT
SCOPE Milk powder is commonly consumed throughout the world. However, advanced glycation end products (AGEs) will form in milk powder during thermal processing and long-term storage. This study aimed to identify such compounds with potential as new urinary biomarkers of intake of heat-treated skimmed milk powder (HSMP). METHODS AND

RESULTS:

A parallel study is performed with different dosages of HSMP as well as hydrolyzed HSMP and untreated skimmed milk powder (SMP) in 36 rats. The 24-h urine samples on day 7 or 8 are collected and profiled by untargeted UPLC-Qtof-MS metabolomics. Statistical analysis revealed 25 metabolites differentiating SMP and HSMP; nineteen of these structures are proposed as lysine- and arginine-derived AGEs, and heterocyclic compounds.

CONCLUSION:

These metabolites may potentially serve as biomarkers of food intake pending further validation to assess intakes of heat-processed dairy foods and thus help to elucidate the effects of HSMP consumption or dietary AGEs on human health.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Glycation End Products, Advanced / Milk Limits: Animals Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2021 Document type: Article Affiliation country: Dinamarca
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Glycation End Products, Advanced / Milk Limits: Animals Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2021 Document type: Article Affiliation country: Dinamarca