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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
Wahis, Jérôme; Baudon, Angel; Althammer, Ferdinand; Kerspern, Damien; Goyon, Stéphanie; Hagiwara, Daisuke; Lefevre, Arthur; Barteczko, Lara; Boury-Jamot, Benjamin; Bellanger, Benjamin; Abatis, Marios; Da Silva Gouveia, Miriam; Benusiglio, Diego; Eliava, Marina; Rozov, Andrei; Weinsanto, Ivan; Knobloch-Bollmann, Hanna Sophie; Kirchner, Matthew K; Roy, Ranjan K; Wang, Hong; Pertin, Marie; Inquimbert, Perrine; Pitzer, Claudia; Siemens, Jan; Goumon, Yannick; Boutrel, Benjamin; Lamy, Christophe Maurice; Decosterd, Isabelle; Chatton, Jean-Yves; Rouach, Nathalie; Young, W Scott; Stern, Javier E; Poisbeau, Pierrick; Stoop, Ron; Darbon, Pascal; Grinevich, Valery; Charlet, Alexandre.
Affiliation
  • Wahis J; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Baudon A; KU Leuven, Leuven Brain Institue, Department of Neurosciences, VIB-KU Leuven Center for Brain and Disease Research, Laboratory of Glia Biology, Leuven, Belgium.
  • Althammer F; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Kerspern D; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta GA, USA.
  • Goyon S; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Hagiwara D; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Lefevre A; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Barteczko L; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Boury-Jamot B; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Bellanger B; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Abatis M; Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Da Silva Gouveia M; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Benusiglio D; Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Eliava M; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rozov A; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Weinsanto I; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Knobloch-Bollmann HS; OpenLab of Neurobiology, Kazan Federal University, Kazan, Russia, Federal Center of Brain Research and Neurotechnologies, Moscow, Russia and Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany.
  • Kirchner MK; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Roy RK; Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge MA, USA.
  • Wang H; Group of Systemic and Cellular Neuroscience, Institute of Physiology, University of Freiburg, Freiburg, Germany.
  • Pertin M; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta GA, USA.
  • Inquimbert P; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta GA, USA.
  • Pitzer C; Department of Pharmacology, Heidelberg University, Heidelberg, Germany.
  • Siemens J; The Brain Cognition and Brain Disease Institute of Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.
  • Goumon Y; Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Boutrel B; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Lamy CM; Interdisciplinary Neurobehavioral Core (INBC), Ruprecht-Karls-Universität, Heidelberg, Germany.
  • Decosterd I; Department of Pharmacology, Heidelberg University, Heidelberg, Germany.
  • Chatton JY; Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg, France.
  • Rouach N; Center for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Young WS; Division of Anatomy, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Stern JE; Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Poisbeau P; Department of Fundamental Neurosciences, Faculty of Biology and Medicine (FBM), University of Lausanne, Lausanne, Switzerland.
  • Stoop R; Pain center, Department of Anesthesiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Darbon P; Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, Centre National de la Recherche Scientifique UMR 7241, Institut National de la Santé et de la Recherche Médicale U1050, Labex Memolife, PSL Research University, Paris, France.
  • Grinevich V; Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Charlet A; Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta GA, USA.
Nat Neurosci ; 24(4): 529-541, 2021 04.
Article in En | MEDLINE | ID: mdl-33589833
ABSTRACT
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxytocin / Astrocytes / Emotions / Central Amygdaloid Nucleus / Neurons Limits: Animals Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2021 Document type: Article Affiliation country: Francia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxytocin / Astrocytes / Emotions / Central Amygdaloid Nucleus / Neurons Limits: Animals Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 2021 Document type: Article Affiliation country: Francia