Clinical manifestations in patients with antiphospholipid antibodies: Beyond thrombosis and pregnancy loss.
Lupus
; 30(6): 884-892, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33593163
ABSTRACT
The clinical spectrum of the antiphospholipid syndrome (APS) encompasses additional manifestations other than thrombosis and pregnancy morbidity, which may potentially affect every organ and system. The pathophysiology of APS indeed cannot be explained exclusively by a prothrombotic state and the "extra-criteria" manifestations of the syndrome should be attributed to other mechanisms, such as inflammation, complement and platelet activation. In this case-series, we report patients with uncommon clinical APS presentations, to highlight relevant peculiarities of the syndrome, potentially paving the way for a further update of clinical as well as laboratory manifestations of this complex immunological condition.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Antiphospholipid Syndrome
/
Antibodies, Antiphospholipid
Type of study:
Etiology_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
Language:
En
Journal:
Lupus
Journal subject:
REUMATOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Italia