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Association of SHANK Family with Neuropsychiatric Disorders: An Update on Genetic and Animal Model Discoveries.
Wan, Lily; Liu, Du; Xiao, Wen-Biao; Zhang, Bo-Xin; Yan, Xiao-Xin; Luo, Zhao-Hui; Xiao, Bo.
Affiliation
  • Wan L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Liu D; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Xiao WB; Taikang Tongji Hospital, Wuhan, 430050, Hubei, China.
  • Zhang BX; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Yan XX; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Luo ZH; Department of Anatomy and Neurobiology, Central South University, Changsha, 410013, Hunan, China.
  • Xiao B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. luozhaohui_xy@126.com.
Cell Mol Neurobiol ; 42(6): 1623-1643, 2022 Aug.
Article in En | MEDLINE | ID: mdl-33595806
ABSTRACT
The Shank family proteins are enriched at the postsynaptic density (PSD) of excitatory glutamatergic synapses. They serve as synaptic scaffolding proteins and appear to play a critical role in the formation, maintenance and functioning of synapse. Increasing evidence from genetic association and animal model studies indicates a connection of SHANK genes defects with the development of neuropsychiatric disorders. In this review, we first update the current understanding of the SHANK family genes and their encoded protein products. We then denote the literature relating their alterations to the risk of neuropsychiatric diseases. We further review evidence from animal models that provided molecular insights into the biological as well as pathogenic roles of Shank proteins in synapses, and the potential relationship to the development of abnormal neurobehavioral phenotypes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Nerve Tissue Proteins Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Cell Mol Neurobiol Year: 2022 Document type: Article Affiliation country: China Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Nerve Tissue Proteins Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Cell Mol Neurobiol Year: 2022 Document type: Article Affiliation country: China Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA