Neuroendocrine neoplasms of the middle ear: Unpredictable tumor behavior and tendency for recurrence.
Head Neck
; 43(6): 1848-1853, 2021 06.
Article
in En
| MEDLINE
| ID: mdl-33605503
ABSTRACT
BACKGROUND:
Middle ear adenomatous neuroendocrine tumors (MEANTs) are rare temporal bone tumors. This study evaluates its clinical behavior and therapy outcome.METHOD:
Retrospective case review in a tertiary referral center evaluating histopathology, immunohistochemistry, treatment, and outcome.RESULTS:
Nine patients were diagnosed with MEANT. One patient presented with locally invasive tumor and underwent extensive en-bloc tumor resection with adjuvant radiotherapy. Seven of eight patients with locally non-aggressive tumor confined to the tympanomastoid space underwent tumor resection. Two patients were disease-free, five presented recurrence, even after apparent successful surgery. All tumors showed neuroendocrine features. Histopathology and immunohistochemistry did not yield prognostic tumor characteristics.CONCLUSION:
MEANTs are rare tumors with uncertain biological behavior and subsequent unpredictable clinical course. The preferred treatment is complete surgical tumor resection. They have a high tendency for recurrence, irrespective of negative intermediary surgery. As of yet, there are no prognostic biomarkers, including histopathology and immunohistochemistry.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ear Neoplasms
/
Neuroendocrine Tumors
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2021
Document type:
Article
Affiliation country:
Países Bajos