First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant.
Enferm Infecc Microbiol Clin (Engl Ed)
; 2021 Feb 19.
Article
in En, Es
| MEDLINE
| ID: mdl-33685741
ABSTRACT
INTRODUCTION:
A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant. MATERIAL ANDMETHODS:
We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing.RESULTS:
We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations.CONCLUSION:
The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
/
Es
Journal:
Enferm Infecc Microbiol Clin (Engl Ed)
Year:
2021
Document type:
Article
Affiliation country:
España
Publication country:
ES
/
ESPANHA
/
ESPAÑA
/
SPAIN