Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP-mediated inflammatory response inhibition.

Keskin, Halil; Keskin, Filiz; Tavaci, Taha; Halici, Hamza; Yuksel, Tugba Nurcan; Ozkaraca, Mustafa; Bilen, Arzu; Halici, Zekai

Keskin, Halil; Keskin, Filiz; Tavaci, Taha; Halici, Hamza; Yuksel, Tugba Nurcan; Ozkaraca, Mustafa; Bilen, Arzu; Halici, Zekai.

Affiliation

Keskin H; Division of Paediatric Intensive Care Unit, Department of Paediatrics, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Keskin F; Division of Paediatric Neurology, Department of Paediatrics, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Tavaci T; Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Halici H; Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Yuksel TN; Department of Pharmacology, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey.
Ozkaraca M; Department of Pathology, Cumhuriyet University Faculty of Veterinary, Sivas, Turkey.
Bilen A; Division of Endocrinology, Department of Internal Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Halici Z; Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Clin Exp Pharmacol Physiol ; 48(8): 1103-1110, 2021 08.

Article in En | MEDLINE | ID: mdl-33686709

Subject(s)
Key words

IL-1ß; IL-6; NLRP3; TNF-α; cerebral ischaemia/reperfusion injury; juvenile rat; roflumilast; stroke

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Neuroprotective Agents / Aminopyridines Limits: Animals Language: En Journal: Clin Exp Pharmacol Physiol Year: 2021 Document type: Article Affiliation country: Turquía Country of publication: Australia

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