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Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.
Wu, Guoxin; Zuck, Paul; Goh, Shih Lin; Milush, Jeffrey M; Vohra, Poonam; Wong, Joseph K; Somsouk, Ma; Yukl, Steven A; Shacklett, Barbara L; Chomont, Nicolas; Haase, Ashley T; Hatano, Hiroyu; Schacker, Timothy W; Deeks, Steven G; Hazuda, Daria J; Hunt, Peter W; Howell, Bonnie J.
Affiliation
  • Wu G; Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Zuck P; Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Goh SL; Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Milush JM; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Vohra P; Division of Pathology and Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Wong JK; Division of Infectious Diseases, Department of Medicine, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, San Francisco, California, USA.
  • Somsouk M; Division of Gastroenterology, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Yukl SA; Division of Infectious Diseases, Department of Medicine, San Francisco Veterans Affairs Health Care System and University of California, San Francisco, San Francisco, California, USA.
  • Shacklett BL; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, USA.
  • Chomont N; Department of Microbiology, Infectiology and Immunology and Centre de Recherche du CHUM, Université de Montréal, Montréal, Quebec, Canada.
  • Haase AT; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Hatano H; Division of HIV, ID, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Schacker TW; Division of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Deeks SG; Division of HIV, ID, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Hazuda DJ; Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Hunt PW; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Howell BJ; Merck & Co, Inc, Kenilworth, New Jersey, USA.
J Infect Dis ; 224(9): 1593-1598, 2021 11 16.
Article in En | MEDLINE | ID: mdl-33693750
ABSTRACT
We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / HIV Core Protein p24 / Gag Gene Products, Human Immunodeficiency Virus Limits: Female / Humans Language: En Journal: J Infect Dis Year: 2021 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / HIV Core Protein p24 / Gag Gene Products, Human Immunodeficiency Virus Limits: Female / Humans Language: En Journal: J Infect Dis Year: 2021 Document type: Article Affiliation country: Estados Unidos