[Effect of physicochemical properties on the pharmacokinetic parameters of the new representative of benzothiazinones antituberculosis drug macozinonÐµ].

Khokhlov, A L; Mariandyshev, A O; Shcherbakova, V S; Ozerova, I V; Kazaishvili, Y G; Igumnova, O V; Bolgarina, A A; Rudoy, B A

Khokhlov, A L; Mariandyshev, A O; Shcherbakova, V S; Ozerova, I V; Kazaishvili, Y G; Igumnova, O V; Bolgarina, A A; Rudoy, B A.

Affiliation

Khokhlov AL; Yaroslavl State Medical University.
Mariandyshev AO; Northern State Medical University.
Shcherbakova VS; NEARMEDIC PHARMA LLC.
Ozerova IV; Zakusov Research Institute of Pharmacology.
Kazaishvili YG; NEARMEDIC PHARMA LLC.
Igumnova OV; NEARMEDIC PHARMA LLC.
Bolgarina AA; NEARMEDIC PHARMA LLC.
Rudoy BA; NEARMEDIC PHARMA LLC.

Ter Arkh ; 92(12): 165-171, 2020 Dec 15.

Article in Ru | MEDLINE | ID: mdl-33720590

Subject(s)
Key words

Biopharmaceutics Classification System (BCS) class,; DprE1; DprE1 inhibitors; PBTZ169; absorption parameters; benzothiazinones; dosage form; maÑozinone; permeability; pharmacokinetic; solubility; the narrow absorption window; tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazines / Antitubercular Agents Limits: Animals / Humans Language: Ru Journal: Ter Arkh Year: 2020 Document type: Article

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