Aminolactonization of Unactivated Alkenes Catalyzed by Aryl Iodine.
J Org Chem
; 86(7): 5152-5165, 2021 04 02.
Article
in En
| MEDLINE
| ID: mdl-33760610
ABSTRACT
A one-step protocol of the aryl iodine-catalyzed aminolactonization of unactivated alkenes under oxidation conditions was first reported to efficiently construct diverse amino lactones in a short time using HNTs2 as the compatible nitrogen source. In addition, we investigated the influence of the reaction rate based on the structure of the iodoarene precatalyst, which revealed the selective adjustment effect on aminolactonization and oxylactonization. Finally, preliminary experiments verified the feasibility of asymmetric aminolactonization catalyzed by a chiral iodoarene precatalyst.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alkenes
/
Iodine
Language:
En
Journal:
J Org Chem
Year:
2021
Document type:
Article
Affiliation country:
China