Longitudinal Association between White Matter Hyperintensities and White Matter Beta-Amyloid Deposition in Cognitively Unimpaired Elderly.
Curr Alzheimer Res
; 18(1): 8-13, 2021.
Article
in En
| MEDLINE
| ID: mdl-33761854
ABSTRACT
BACKGROUND:
White matter (WM) beta-amyloid uptake has been used as a reference region to calculate the cortical standard uptake value ratio (SUVr). However, white matter hyperintensities (WMH) may have an influence on WM beta-amyloid uptake. Our study aimed to investigate the associations between WMH and WM beta-amyloid deposition in cognitively unimpaired elderly.METHODS:
Data from 83 cognitively unimpaired individuals in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset were analyzed. All participants had complete baseline and four-year follow-up information about WMH volume, WM 18F-AV-45 SUVr, and cognitive function, including ADNI-Memory (ADNI-Mem) and ADNI-Executive function (ADNI-EF) scores. Cross-sectional and longitudinal linear regression analyses were used to determine the associations between WMH and WM SUVr and cognitive measures.RESULTS:
Lower WM 18F-AV-45 SUVr at baseline was associated with younger age (ß=0.01, P=0.037) and larger WMH volume (ß=-0.049, P=0.048). The longitudinal analysis found an annual increase in WM 18F-AV-45 SUVr was associated with an annual decrease in WMH volume (ß=-0.016, P=0.041). An annual decrease in the ADNI-Mem score was associated with an annual increase in WMH volume (ß=-0.070, P=0.001), an annual decrease in WM 18F-AV-45 SUVr (ß=0.559, P=0.030), and fewer years of education (ß=0.011, P=0.044). There was no significant association between WM 18F-AV-45 SUVr and ADNI-EF (P>0.05).CONCLUSION:
Reduced beta-amyloid deposition in WM was associated with higher WMH load and memory decline in cognitively unimpaired elderly. WMH volume should be considered when WM 18F-AV-45 SUVr is used as a reference for evaluating cortical 18F-AV-45 SUVr.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Journal:
Curr Alzheimer Res
Journal subject:
NEUROLOGIA
Year:
2021
Document type:
Article
Affiliation country:
China