Analysis of patterns of bacteremia and 30-day mortality in patients with acute cholangitis over a 25-year period.
Scand J Gastroenterol
; 56(5): 578-584, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33764841
ABSTRACT
INTRODUCTION:
Acute cholangitis (AC) is a condition of bacterial infection in the biliary tract with a high mortality rate of around 10%. Direct association between presence of bacteremia and 30-day mortality among AC patients is sparsely investigated and remains unclear. AIMS ANDMETHODS:
Our aim was to investigate association between bacteremia and 30-day mortality among patients with AC included over a period of 25 years. All AC patients that underwent endoscopic retrograde cholangiopancreatography (ERCP) at Odense University Hospital, between 1 January 1990 and 31 October 2015, were identified using a prospective ERCP database. Blood culture results from the patients along with antimicrobial resistance patterns were collected from a bacteremia research database.RESULTS:
During the study period, 775 consecutive AC patients underwent ERCP and blood cultures were collected from 528 patients. Among these patients 48% (n = 260) had bacteremia. Overall, 30-day mortality in patients with blood cultures performed was 13% (n = 69). In patients with bacteremia, 30-day mortality was 19% (n = 49), compared to 7% (n = 20) in patients without bacteremia (p < .01). Presence of bacteremia was associated with increased 30-day mortality (OR [95% CI] 3.43 [1.92-6.13]; p < .01) following adjustment for confounding factors. Among the species, bacteremia with Enterobacter cloacae was significantly associated with increased 30-day mortality (OR [95% CI] 2.97 [1.16-7.62]; p = .02).CONCLUSION:
Our results indicate that presence of bacteremia was associated with a nearly fourfold increase in 30-day mortality among AC patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Infections
/
Cholangitis
/
Bacteremia
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Scand J Gastroenterol
Year:
2021
Document type:
Article
Affiliation country:
Dinamarca