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Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial.
Emary, Katherine R W; Golubchik, Tanya; Aley, Parvinder K; Ariani, Cristina V; Angus, Brian; Bibi, Sagida; Blane, Beth; Bonsall, David; Cicconi, Paola; Charlton, Sue; Clutterbuck, Elizabeth A; Collins, Andrea M; Cox, Tony; Darton, Thomas C; Dold, Christina; Douglas, Alexander D; Duncan, Christopher J A; Ewer, Katie J; Flaxman, Amy L; Faust, Saul N; Ferreira, Daniela M; Feng, Shuo; Finn, Adam; Folegatti, Pedro M; Fuskova, Michelle; Galiza, Eva; Goodman, Anna L; Green, Catherine M; Green, Christopher A; Greenland, Melanie; Hallis, Bassam; Heath, Paul T; Hay, Jodie; Hill, Helen C; Jenkin, Daniel; Kerridge, Simon; Lazarus, Rajeka; Libri, Vincenzo; Lillie, Patrick J; Ludden, Catherine; Marchevsky, Natalie G; Minassian, Angela M; McGregor, Alastair C; Mujadidi, Yama F; Phillips, Daniel J; Plested, Emma; Pollock, Katrina M; Robinson, Hannah; Smith, Andrew; Song, Rinn.
Affiliation
  • Emary KRW; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Golubchik T; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Ariani CV; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
  • Angus B; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Blane B; COVID-19 Genomics UK, Department of Medicine, University of Cambridge, Cambridge, UK.
  • Bonsall D; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Cicconi P; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Charlton S; National Infection Service, Public Health England, Salisbury, UK.
  • Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Collins AM; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Cox T; UK Biocentre, Milton Keynes, UK.
  • Darton TC; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Douglas AD; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Duncan CJA; Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, Newcastle upon Tyne, UK.
  • Ewer KJ; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Flaxman AL; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
  • Ferreira DM; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Feng S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Finn A; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
  • Folegatti PM; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Fuskova M; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Galiza E; St George's Vaccine Institute, St George's, University of London, London, UK.
  • Goodman AL; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
  • Green CM; Clinical BioManufacturing Facility, University of Oxford, Oxford, UK.
  • Green CA; NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Hallis B; National Infection Service, Public Health England, Salisbury, UK.
  • Heath PT; St George's Vaccine Institute, St George's, University of London, London, UK.
  • Hay J; University of Glasgow, Glasgow, UK; Lighthouse Laboratory in Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.
  • Hill HC; Department of Clinical Sciences, Liverpool School of Tropical Medicine and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Jenkin D; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Kerridge S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Lazarus R; Severn Pathology, North Bristol NHS Trust, Bristol, UK.
  • Libri V; NIHR UCLH Clinical Research Facility, London, UK; NIHR UCLH Biomedical Research Centre, London, UK.
  • Lillie PJ; Hull University Teaching Hospitals NHS Trust, Hull, UK.
  • Ludden C; COVID-19 Genomics UK, Department of Medicine, University of Cambridge, Cambridge, UK.
  • Marchevsky NG; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Minassian AM; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • McGregor AC; London Northwest University Healthcare, Harrow, UK.
  • Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Phillips DJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Pollock KM; NIHR Imperial Clinical Research Facility, London, UK; NIHR Imperial Biomedical Research Centre, London, UK.
  • Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Smith A; College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital and School, University of Glasgow, Glasgow, UK.
  • Song R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Lancet ; 397(10282): 1351-1362, 2021 04 10.
Article in En | MEDLINE | ID: mdl-33798499
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Lancet Year: 2021 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Lancet Year: 2021 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido