Hippocampal and insula volume in mild cognitive impairment with Lewy bodies.
Parkinsonism Relat Disord
; 86: 27-33, 2021 05.
Article
in En
| MEDLINE
| ID: mdl-33823470
ABSTRACT
INTRODUCTION:
Diagnostic criteria for prodromal dementia with Lewy bodies have recently been published. These include the use of imaging biomarkers to distinguish mild cognitive impairment with Lewy bodies (MCI-LB) from MCI due to other causes. Two potential biomarkers listed, though not formally included in the diagnostic criteria, due to insufficient evidence, are relatively preserved hippocampi, and atrophy of the insula cortex on structural brain imaging.METHODS:
In this report, we sought to investigate these imaging biomarkers in 105 research subjects, including well characterised groups of patients with MCI-LB (n = 38), MCI with no core features of Lewy body disease (MCI-AD; n = 36) and healthy controls (N = 31). Hippocampal and insula volumes were determined from T1 weighted structural MRI scans, using grey matter segmentation performed with SPM software.RESULTS:
Adjusting for age, sex and intracranial volume, there were no differences in hippocampal or insula volume between MCI-AD and MCI-LB, although in both conditions volumes were significantly reduced relative to controls.CONCLUSION:
Our results do not support the use of either hippocampal or insula volume to identify prodromal dementia with Lewy bodies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lewy Body Disease
/
Cognitive Dysfunction
/
Insular Cortex
/
Hippocampus
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Parkinsonism Relat Disord
Journal subject:
NEUROLOGIA
Year:
2021
Document type:
Article