Recombinant SARS-CoV-2 S Protein Binds to Glycans of the Lactosamine Family in vitro.
Biochemistry (Mosc)
; 86(3): 243-247, 2021 Mar.
Article
in En
| MEDLINE
| ID: mdl-33838626
ABSTRACT
Many viruses, beside binding to their main cell target, interact with other molecules that promote virus adhesion to the cell; often, these additional targets are glycans. The main receptor for SARS-CoV-2 is a peptide motif in the ACE2 protein. We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family. We suggest that parallel influenza infection will promote SARS-CoV-2 adhesion to the respiratory epithelial cells due to the unmasking of lactosamine chains by the influenza virus neuraminidase.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polysaccharides
/
Spike Glycoprotein, Coronavirus
/
SARS-CoV-2
/
COVID-19
/
Amino Sugars
Limits:
Humans
Language:
En
Journal:
Biochemistry (Mosc)
Year:
2021
Document type:
Article
Affiliation country:
Rusia