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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
Lugar, Charles W; Clarke, Christian A; Morphy, Richard; Rudyk, Helene; Sapmaz, Selma; Stites, Ryan E; Vaught, Grant M; Furness, Kelly; Broughton, Howard B; Durst, Greg L; Clawson, David K; Stout, Stephanie L; Guo, Sherry Y; Durbin, Jim D; Stayrook, Keith R; Edmondson, Denise D; Kikly, Kristy; New, Nicole E; Bina, Holly A; Chambers, Mark G; Shetler, Pamela; Chang, William Y; Chang, Veavi Ching-Yun; Barr, Rob; Gough, Wendy H; Steele, Jimmy P; Getman, Brian; Patel, Nita; Mathes, Brian M; Richardson, Timothy I.
Affiliation
  • Lugar CW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Clarke CA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Morphy R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Rudyk H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Sapmaz S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Stites RE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Vaught GM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Furness K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Broughton HB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Durst GL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Clawson DK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Stout SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Guo SY; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Durbin JD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Stayrook KR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Edmondson DD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Kikly K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • New NE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Bina HA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Chambers MG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Shetler P; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Chang WY; Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California 92121, United States.
  • Chang VC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Barr R; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Gough WH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Steele JP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Getman B; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Patel N; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Mathes BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
  • Richardson TI; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
J Med Chem ; 64(9): 5470-5484, 2021 05 13.
Article in En | MEDLINE | ID: mdl-33852312
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Nuclear Receptor Subfamily 1, Group F, Member 3 / Ligands Type of study: Guideline Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Nuclear Receptor Subfamily 1, Group F, Member 3 / Ligands Type of study: Guideline Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos