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Human KIT+ myeloid cells facilitate visceral metastasis by melanoma.
Yu, Chun I; Martinek, Jan; Wu, Te-Chia; Kim, Kyung In; George, Joshy; Ahmadzadeh, Elaheh; Maser, Rick; Marches, Florentina; Metang, Patrick; Authie, Pierre; Oliveira, Vanessa K P; Wang, Victor G; Chuang, Jeffrey H; Robson, Paul; Banchereau, Jacques; Palucka, Karolina.
Affiliation
  • Yu CI; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Martinek J; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
  • Wu TC; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Kim KI; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • George J; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Ahmadzadeh E; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Maser R; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Marches F; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
  • Metang P; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Authie P; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
  • Oliveira VKP; The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME.
  • Wang VG; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Robson P; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT.
  • Banchereau J; The Jackson Laboratory for Genomic Medicine, Farmington, CT.
  • Palucka K; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT.
J Exp Med ; 218(6)2021 06 07.
Article in En | MEDLINE | ID: mdl-33857287
Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising <4% of the human CD45+ leukocytes. Metastatic tumor-infiltrating CD33+ cells from patients and humanized (h)NSG-SGM3 mice showed converging transcriptional profiles. Single-cell RNA-seq analysis identified a gene signature of a KIT/CD117-expressing CD33+ subset that correlated with decreased overall survival in a TCGA melanoma cohort. Thus, human CD33+CD11b+CD117+ myeloid cells represent a novel candidate biomarker as well as a therapeutic target for metastatic melanoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-kit / Myeloid Cells / Melanoma Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2021 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-kit / Myeloid Cells / Melanoma Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2021 Document type: Article Country of publication: Estados Unidos