Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.

Ly, Justin Q; Wong, Susan; Liu, Liling; Li, Ruina; Messick, Kirsten; Chang, Jae H

Ly, Justin Q; Wong, Susan; Liu, Liling; Li, Ruina; Messick, Kirsten; Chang, Jae H.

Affiliation

Ly JQ; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.).
Wong S; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.).
Liu L; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.).
Li R; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.).
Messick K; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.).
Chang JH; Genentech, Inc., South San Francisco, California (J.Q.L., S.W., L.L., R.L., K.M.), and ORIC Pharmaceuticals, South San Francisco, California (J.H.C.) jaechang@gmail.com.

Drug Metab Dispos ; 49(7): 540-547, 2021 07.

Article in En | MEDLINE | ID: mdl-33863817

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP3A Inducers Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Country of publication: Estados Unidos

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