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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.
Dai, Wenhao; Jochmans, Dirk; Xie, Hang; Yang, Hang; Li, Jian; Su, Haixia; Chang, Di; Wang, Jiang; Peng, Jingjing; Zhu, Lili; Nian, Yong; Hilgenfeld, Rolf; Jiang, Hualiang; Chen, Kaixian; Zhang, Leike; Xu, Yechun; Neyts, Johan; Liu, Hong.
Affiliation
  • Dai W; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Jochmans D; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xie H; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium.
  • Yang H; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Li J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
  • Su H; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Chang D; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Qixia District, Nanjing, 210023, China.
  • Wang J; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Peng J; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zhu L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
  • Nian Y; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Hilgenfeld R; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Jiang H; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
  • Chen K; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Zhang L; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xu Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
  • Neyts J; State Key Laboratory of Drug Research, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • Liu H; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Qixia District, Nanjing, 210023, China.
J Med Chem ; 65(4): 2794-2808, 2022 02 24.
Article in En | MEDLINE | ID: mdl-33872498
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Cysteine Proteinase Inhibitors / Enterovirus / Aldehydes / Peptidomimetics / SARS-CoV-2 Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Cysteine Proteinase Inhibitors / Enterovirus / Aldehydes / Peptidomimetics / SARS-CoV-2 Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos