Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons.
J Neurophysiol
; 125(5): 2000-2012, 2021 05 01.
Article
in En
| MEDLINE
| ID: mdl-33881911
ABSTRACT
This study demonstrates that the action potential discharge in vagal afferent A-fiber neurons is about 20 times more sensitive to the rate of membrane depolarization compared to C-fiber neurons. The sensitivity of action potential generation to the depolarization rate in vagal sensory neurons is independent of the intensity of current stimuli but nearly abrogated by inhibiting the D-type potassium channel. These findings help better understand the mechanisms that control the activation of vagal afferent nerves.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Action Potentials
/
Nerve Fibers, Unmyelinated
/
Shaker Superfamily of Potassium Channels
/
Nerve Fibers, Myelinated
/
Neurons, Afferent
/
Nodose Ganglion
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
J Neurophysiol
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos