Recovery of the brain after intraventricular hemorrhage.
Semin Fetal Neonatal Med
; 27(1): 101224, 2022 02.
Article
in En
| MEDLINE
| ID: mdl-33888444
ABSTRACT
Intraventricular hemorrhage (IVH) remains a major complication of prematurity, worldwide. The severity of IVH is variable, ranging from a tiny germinal matrix bleed to a moderate-to-large ventricular hemorrhage or periventricular hemorrhagic infarction. Survivors with IVH often suffer from hydrocephalus and white matter injury. There is no tangible treatment to prevent post-hemorrhagic cerebral palsy, cognitive deficits, or hydrocephalus in these infants. White matter injury is attributed to blood-induced damage to axons and maturing oligodendrocyte precursors, resulting in reduced myelination and axonal loss. Hydrocephalus results from obstructed CSF circulation by blood clots, increased CSF production, and reduced CSF absorption by lymphatics and arachnoid villi. Several strategies to promote neurological recovery have shown promise in animal models, including the elimination of blood and blood products, alleviating cerebral inflammation and oxidative stress, as well as promoting survival and maturation of oligodendrocyte precursors. The present review integrates novel mechanisms of brain injury in IVH and the imminent therapies to alleviate post-hemorrhagic white matter injury and hydrocephalus in the survivors with IVH.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Injuries
/
Hydrocephalus
/
Infant, Premature, Diseases
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
/
Newborn
Language:
En
Journal:
Semin Fetal Neonatal Med
Journal subject:
PEDIATRIA
/
PERINATOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Estados Unidos