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The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids.
Hoenke, Sophie; Christoph, Martin A; Friedrich, Sander; Heise, Niels; Brandes, Benjamin; Deigner, Hans-Peter; Al-Harrasi, Ahmed; Csuk, René.
Affiliation
  • Hoenke S; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
  • Christoph MA; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
  • Friedrich S; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
  • Heise N; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
  • Brandes B; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
  • Deigner HP; Institute of Precision Medicine, Medical and Life Science Faculty, Furtwangen University, Jakob-Kienzle-Str. 17, D-78054 Villigen-Schwenningen, Germany.
  • Al-Harrasi A; Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkat Al-Mauz, PC 616 Nizwa, Oman.
  • Csuk R; Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
Molecules ; 26(7)2021 Apr 06.
Article in En | MEDLINE | ID: mdl-33917636
Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9-31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC50 = 0.6 µM for HT29 colon adenocarcinoma cells).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclohexylamines / Pentacyclic Triterpenes Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Suiza
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclohexylamines / Pentacyclic Triterpenes Limits: Animals / Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Alemania Country of publication: Suiza