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Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease "sanctuary" during venetoclax treatment?
Dimou, Maria; Bitsani, Aikaterini; Roumelioti, Maria; Dimitrakopoulou, Aglaia; Iliakis, Theodore; Pardalis, Vasileios; Grafakos, Ioannis; Kalyva, Sotiria; Markopoulos, Athanasios; Kyrtsonis, Marie-Christine; Panayiotidis, Panayiotis.
Affiliation
  • Dimou M; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Bitsani A; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Roumelioti M; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Dimitrakopoulou A; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Iliakis T; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Pardalis V; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Grafakos I; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Kalyva S; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Markopoulos A; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Kyrtsonis MC; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
  • Panayiotidis P; 1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece.
Clin Case Rep ; 9(4): 2249-2253, 2021 Apr.
Article in En | MEDLINE | ID: mdl-33936674
ABSTRACT
Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Case Rep Year: 2021 Document type: Article
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Case Rep Year: 2021 Document type: Article