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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Schulte, Christie A; Deaton, David N; Diaz, Elsie; Do, Young; Gampe, Robert T; Guss, Jeffrey H; Hancock, Ashley P; Hobbs, Heather; Hodgson, Simon T; Holt, Jason; Jeune, Michael R; Kahler, Kirsten M; Kramer, H Fritz; Le, Joelle; Mortenson, Paul N; Musetti, Caterina; Nolte, Robert T; Orband-Miller, Lisa A; Peckham, Gregory E; Petrov, Kim G; Pietrak, Beth L; Poole, Chuck; Price, Daniel J; Saxty, Gordon; Shillings, Anthony; Smalley, Terrence L; Somers, Don O; Stewart, Eugene L; Stuart, J Darren; Thomson, Stephen A.
Affiliation
  • Schulte CA; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States. Electronic address: christie.a.schulte@gsk.com.
  • Deaton DN; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Diaz E; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Do Y; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Gampe RT; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Guss JH; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States.
  • Hancock AP; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Hobbs H; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Hodgson ST; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Holt J; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Jeune MR; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Kahler KM; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Kramer HF; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Le J; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Mortenson PN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.
  • Musetti C; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States.
  • Nolte RT; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States.
  • Orband-Miller LA; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Peckham GE; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Petrov KG; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Pietrak BL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States.
  • Poole C; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Price DJ; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Saxty G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.
  • Shillings A; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Smalley TL; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Somers DO; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
  • Stewart EL; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Stuart JD; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
  • Thomson SA; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, United States.
Bioorg Med Chem Lett ; 47: 128113, 2021 09 01.
Article in En | MEDLINE | ID: mdl-33991628
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Drug Discovery Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Drug Discovery Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Document type: Article Country of publication: Reino Unido