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Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study.
Lu, Meng; Xueying, Qin; Hexiang, Peng; Wenjing, Gao; Hägg, Sara; Weihua, Cao; Chunxiao, Li; Canqing, Yu; Jun, Lv; Zengchang, Pang; Liming, Cong; Hua, Wang; Xianping, Wu; Yunzhang, Wang; Liming, Li.
Affiliation
  • Lu M; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Xueying Q; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Hexiang P; Department of Medical Epidemiology & Biostatistics, Karolinska Institute, 171 76 Stockholm, Sweden.
  • Wenjing G; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Hägg S; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Weihua C; Department of Medical Epidemiology & Biostatistics, Karolinska Institute, 171 76 Stockholm, Sweden.
  • Chunxiao L; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Canqing Y; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Jun L; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Zengchang P; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
  • Liming C; Qingdao Center for Disease Control & Prevention, Qingdao 266033, PR China.
  • Hua W; Zhejiang Center for Disease Control & Prevention, Hangzhou 310051, PR China.
  • Xianping W; Jiangsu Center for Disease Control & Prevention, Nanjing 210009, PR China.
  • Yunzhang W; Sichuan Center for Disease Control & Prevention, Chengdu 610041, PR China.
  • Liming L; Department of Medical Epidemiology & Biostatistics, Karolinska Institute, 171 76 Stockholm, Sweden.
Epigenomics ; 13(12): 939-951, 2021 06.
Article in En | MEDLINE | ID: mdl-33993705
ABSTRACT

Aim:

Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials &

methods:

In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip.

Results:

Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins.

Conclusion:

The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Drinking / Biomarkers / DNA Methylation / Genome-Wide Association Study / Cell-Free Nucleic Acids Type of study: Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Epigenomics Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Drinking / Biomarkers / DNA Methylation / Genome-Wide Association Study / Cell-Free Nucleic Acids Type of study: Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Epigenomics Year: 2021 Document type: Article