Bottom-up reconstitution of focal adhesion complexes.
FEBS J
; 289(12): 3360-3373, 2022 06.
Article
in En
| MEDLINE
| ID: mdl-33999507
ABSTRACT
Focal adhesions (FA) are large macromolecular assemblies relevant for various cellular and pathological events such as migration, polarization, and metastatic cancer formation. At FA sites at the migrating periphery of a cell, hundreds of players gather and form a network to respond to extra cellular stimuli transmitted by the integrin receptor, the most upstream component within a cell, initiating the FA signaling pathway. Numerous cellular experiments have been performed to understand the FA architecture and functions; however, their intricate network formation hampers unraveling the precise molecular actions of individual players. Here, in vitro bottom-up reconstitution presents an advantageous approach for elucidating the FA machinery and the hierarchical crosstalk of involved cellular players.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Talin
/
Focal Adhesions
Language:
En
Journal:
FEBS J
Journal subject:
BIOQUIMICA
Year:
2022
Document type:
Article
Affiliation country:
Alemania