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TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway.
Lv, Zhongyang; Xu, Xingquan; Sun, Ziying; Yang, Yannick Xiaofan; Guo, Hu; Li, Jiawei; Sun, Kuoyang; Wu, Rui; Xu, Jia; Jiang, Qing; Ikegawa, Shiro; Shi, Dongquan.
Affiliation
  • Lv Z; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Xu X; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
  • Sun Z; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Yang YX; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
  • Guo H; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Li J; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
  • Sun K; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Wu R; Drum Tower of Clinical Medicine, Nanjing Medical University, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Xu J; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Jiang Q; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
  • Ikegawa S; State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
  • Shi D; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Cell Death Dis ; 12(6): 504, 2021 05 18.
Article in En | MEDLINE | ID: mdl-34006826
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Calcium Signaling / TRPV Cation Channels / NF-E2-Related Factor 2 / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Macrophages Type of study: Prognostic_studies Limits: Aged / Animals / Humans / Male / Middle aged Language: En Journal: Cell Death Dis Year: 2021 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Calcium Signaling / TRPV Cation Channels / NF-E2-Related Factor 2 / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Macrophages Type of study: Prognostic_studies Limits: Aged / Animals / Humans / Male / Middle aged Language: En Journal: Cell Death Dis Year: 2021 Document type: Article Country of publication: Reino Unido