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BNT162b2 mRNA COVID-19 Vaccine Effectiveness in the Prevention of SARS-CoV-2 Infection: A Preliminary Report.
Bianchi, Francesco Paolo; Germinario, Cinzia Annatea; Migliore, Giovanni; Vimercati, Luigi; Martinelli, Andrea; Lobifaro, Annamaria; Tafuri, Silvio; Stefanizzi, Pasquale.
Affiliation
  • Bianchi FP; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
  • Germinario CA; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
  • Migliore G; Bari Policlinico General Hospital, Bari, Italy.
  • Vimercati L; Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy.
  • Martinelli A; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
  • Lobifaro A; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
  • Tafuri S; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
  • Stefanizzi P; Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy.
J Infect Dis ; 224(3): 431-434, 2021 08 02.
Article in En | MEDLINE | ID: mdl-34007998
ABSTRACT
In the preregistration trial, data on efficacy of BNT162b2 mRNA vaccine against SARS-CoV-2 infection were not collected. This study aimed to evaluate vaccine effectiveness (VE) against documented infection. Bari Policlinico University Hospital health care workers (HCWs) who completed the vaccination schedule were matched with HCWs who had refused vaccination. VE for documented infection was 61.9% (95% confidence interval [CI], 19.2%-82.0%) 14-20 days after first dose, 87.9% (95% CI, 51.7%-97.0%) 21-27 days after first dose, and 96.0% (95% CI, 82.2%-99.1%) 7 or more days after second dose. Unvaccinated HCWs remain a concern in the context of the pandemic emergency.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Infect Dis Year: 2021 Document type: Article Affiliation country: Italia
Fulltext
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Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Infect Dis Year: 2021 Document type: Article Affiliation country: Italia