Angiotensin II induces cognitive decline and anxiety-like behavior via disturbing pattern of theta-gamma oscillations.
Brain Res Bull
; 174: 84-91, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34090935
ABSTRACT
Hypertension is the most common chronic disease accompanied by cognitive decline and anxiety-like behavior. Angiotensin II (Ang II) induces hypertension by activating angiotensin II receptor subtype 1 (AT1R). The purpose of the study was to examine the potential underlying mechanism of alterations in cognition and anxiety-like behavior induced by Ang II. Adult C57 mice were intraperitoneal injected with either 1 mg/kg/d Ang II or saline individually for 14 consecutive days. Ang II resulted in cognitive decline and anxious like behavior in C57 mice. Moreover, Ang II disturbed bidirectional synaptic plasticity and neural oscillation coupling between high theta and gamma on PP (perforant pathway)-DG (dentate gyrus) pathway. In addition, Ang II decreased the expression of N-methyl-d-aspartate receptor (NR) 2A and NR 2B and increased the expression of GABAAR α1. The data suggest that Ang II disturb neural oscillations via altering excitatory and inhibitory (E/I) balance and eventually damage cognition and anxiety-like behavior in mice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety
/
Theta Rhythm
/
Behavior, Animal
/
Angiotensin II
/
Cognitive Dysfunction
/
Gamma Rhythm
Limits:
Animals
Language:
En
Journal:
Brain Res Bull
Year:
2021
Document type:
Article