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Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.
Scholz, Okka; Otter, Silke; Welters, Alena; Wörmeyer, Laura; Dolensek, Jurij; Klemen, Masa Skelin; Pohorec, Viljem; Eberhard, Daniel; Mrugala, Jessica; Hamacher, Anna; Koch, Angela; Sanz, Miguel; Hoffmann, Torsten; Hogeback, Jens; Herebian, Diran; Klöcker, Nikolaj; Piechot, Alexander; Mayatepek, Ertan; Meissner, Thomas; Stozer, Andraz; Lammert, Eckhard.
Affiliation
  • Scholz O; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Center of Competence for Innovative Diab
  • Otter S; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Center of Competence for Innovative Diab
  • Welters A; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Wörmeyer L; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Dolensek J; Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia; Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, 2000 Maribor, Slovenia.
  • Klemen MS; Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
  • Pohorec V; Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
  • Eberhard D; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Mrugala J; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; German Center for Diabetes Research (DZD
  • Hamacher A; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Koch A; Institute of Neuro- and Sensory Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Sanz M; Center of Competence for Innovative Diabetes Therapy (KomIT), German Diabetes Center (DDZ), 40225 Düsseldorf, Germany; Taros Chemicals GmbH & Co. KG, 44227 Dortmund, Germany.
  • Hoffmann T; Center of Competence for Innovative Diabetes Therapy (KomIT), German Diabetes Center (DDZ), 40225 Düsseldorf, Germany; Taros Chemicals GmbH & Co. KG, 44227 Dortmund, Germany.
  • Hogeback J; A&M Labor für Analytik und Metabolismusforschung Service GmbH, 50126 Bergheim, Germany.
  • Herebian D; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Klöcker N; Institute of Neuro- and Sensory Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Piechot A; Center of Competence for Innovative Diabetes Therapy (KomIT), German Diabetes Center (DDZ), 40225 Düsseldorf, Germany; Taros Chemicals GmbH & Co. KG, 44227 Dortmund, Germany.
  • Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Meissner T; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Stozer A; Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
  • Lammert E; Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Center of Competence for Innovative Diab
Cell Chem Biol ; 28(10): 1474-1488.e7, 2021 10 21.
Article in En | MEDLINE | ID: mdl-34118188
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Islets of Langerhans / Dextromethorphan / Hypoglycemic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cell Chem Biol Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Islets of Langerhans / Dextromethorphan / Hypoglycemic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Cell Chem Biol Year: 2021 Document type: Article