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Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.
Park, Sung-Jun; Ahmad, Faiyaz; Bahde, Robert J; Philp, Andrew; Kim, Jeonghan; Huang, Tianjiao; Kim, Myung K; Trenkle, William C; Chung, Jay H.
Affiliation
  • Park SJ; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Ahmad F; Department of Pediatric Medicine, Division of Endocrinology, Sidra Medical and Research Center, Doha, Qatar.
  • Bahde RJ; Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Philp A; Mitochondrial Metabolism and Ageing Laboratory, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Australia.
  • Kim J; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Huang T; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Kim MK; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Trenkle WC; Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Chung JH; Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
PLoS One ; 16(6): e0253269, 2021.
Article in En | MEDLINE | ID: mdl-34138962
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Adenylate Kinase / Sirtuin 1 / Phosphodiesterase 4 Inhibitors / Mitochondria, Muscle Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Adenylate Kinase / Sirtuin 1 / Phosphodiesterase 4 Inhibitors / Mitochondria, Muscle Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos