Correlation between the Polymorphism of Coagulation-Related Genes and Lower Extremity Deep Venous Thrombosis.
Fa Yi Xue Za Zhi
; 37(2): 145-150, 2021 Apr.
Article
in En, Zh
| MEDLINE
| ID: mdl-34142473
ABSTRACT
ABSTRACT Objective To investigate the correlation between the polymorphism of 4 coagulation-related genes, rs1799963 ï¼coagulation factor V gene Leidenï¼, rs6025 ï¼prothrombin gene G20210Aï¼, rs1042579 ï¼thrombomodulin protein gene c.1418C>Tï¼ and rs1801131 ï¼methylenetetrahydroflate reductase geneï¼ and lower extremity deep venous thrombosis ï¼LEDVTï¼. Methods The 4 genotypes mentioned above of 150 LEDVT patients and 153 healthy controls were detected by the kompetitive allele specific polymerase chain reaction ï¼KASPï¼, then related blood biochemical indicators were collected, binary Logistic regression was established to screen the independent risk factors of LEDVT, and the correlation between polymorphism of 4 coagulation-related genes and LEDVT and its indicators under different genetic modes after adjusting confounding factors were analyzed. Results Five variables, D-dimer, fibrinogen degradation product, homocysteine, sex and age might be the risk factors of LEDVT. These variables were put into 4 genetic inheritance models, and adjusted in binary Logistic regression. The results suggested that the mutations of rs1042579 were correlated with LEDVT under dominant inheritance mode. Conclusion The gene polymorphism of rs1799963, rs6025 and rs1801131 has no significant correlation with the formation of LEDVT. The gene polymorphism of rs1042579 plays a role under dominant inheritance mode, and might be an independent risk factor for formation of LEDVT.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Venous Thrombosis
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
/
Zh
Journal:
Fa Yi Xue Za Zhi
Journal subject:
JURISPRUDENCIA
Year:
2021
Document type:
Article
Affiliation country:
China