Novel molecular insights and public omics data in pulmonary hypertension.
Biochim Biophys Acta Mol Basis Dis
; 1867(10): 166200, 2021 10 01.
Article
in En
| MEDLINE
| ID: mdl-34144090
ABSTRACT
Pulmonary hypertension is a rare disease with high morbidity and mortality which mainly affects women of reproductive age. Despite recent advances in understanding the pathogenesis of pulmonary hypertension, the high heterogeneity in the presentation of the disease among different patients makes it difficult to make an accurate diagnosis and to apply this knowledge to effective treatments. Therefore, new studies are required to focus on translational and personalized medicine to overcome the lack of specificity and efficacy of current management. Here, we review the majority of public databases storing 'omics' data of pulmonary hypertension studies, from animal models to human patients. Moreover, we review some of the new molecular mechanisms involved in the pathogenesis of pulmonary hypertension, including non-coding RNAs and the application of 'omics' data to understand this pathology, hoping that these new approaches will provide insights to guide the way to personalized diagnosis and treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypertension, Pulmonary
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochim Biophys Acta Mol Basis Dis
Year:
2021
Document type:
Article