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Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Nicolaou, K C; Rigol, Stephan; Pitsinos, Emmanuel N; Das, Dipendu; Lu, Yong; Rout, Subhrajit; Schammel, Alexander W; Holte, Dane; Lin, Baiwei; Gu, Christine; Sarvaiya, Hetal; Trinidad, Jose; Barbour, Nicole; Valdiosera, Amanda M; Sandoval, Joseph; Lee, Christina; Aujay, Monette; Fernando, Hanan; Dhar, Anukriti; Karsunky, Holger; Taylor, Nicole; Pysz, Marybeth; Gavrilyuk, Julia.
Affiliation
  • Nicolaou KC; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005; kcn@rice.edu julia.gavrilyuk@gmail.com.
  • Rigol S; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005.
  • Pitsinos EN; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005.
  • Das D; Laboratory of Natural Products Synthesis & Bioorganic Chemistry, Institute of Nanoscience and Nanotechnology, National Centre for Scientific Research "Demokritos", 153 10 Agia Paraskevi, Greece.
  • Lu Y; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005.
  • Rout S; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005.
  • Schammel AW; BioScience Research Collaborative, Department of Chemistry, Rice University, Houston, TX 77005.
  • Holte D; Discovery Chemistry Department, AbbVie Inc., South San Francisco, CA 94080.
  • Lin B; Discovery Chemistry Department, AbbVie Inc., South San Francisco, CA 94080.
  • Gu C; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Sarvaiya H; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Trinidad J; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Barbour N; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Valdiosera AM; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Sandoval J; Bioconjugation and Process Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Lee C; Assay Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Aujay M; Assay Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Fernando H; Assay Development Department, AbbVie Inc., South San Francisco, CA 94080.
  • Dhar A; Cancer Biology Department, AbbVie Inc., South San Francisco, CA 94080.
  • Karsunky H; Cancer Biology Department, AbbVie Inc., South San Francisco, CA 94080.
  • Taylor N; Cancer Biology Department, AbbVie Inc., South San Francisco, CA 94080.
  • Pysz M; In Vivo Pharmacology Department, AbbVie Inc., South San Francisco, CA 94080.
  • Gavrilyuk J; In Vivo Pharmacology Department, AbbVie Inc., South San Francisco, CA 94080.
Proc Natl Acad Sci U S A ; 118(25)2021 06 22.
Article in En | MEDLINE | ID: mdl-34155147
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthraquinones / Immunoconjugates / Bystander Effect Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthraquinones / Immunoconjugates / Bystander Effect Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: Estados Unidos