FeCl2-Mediated Regioselective Aminochlorination and Aminoazidation of Styrenes with Trifluoromethanesulfonyl Azide.
Org Lett
; 23(13): 5102-5106, 2021 Jul 02.
Article
in En
| MEDLINE
| ID: mdl-34156853
ABSTRACT
An efficient aminochlorination reaction of stryenes is described using N3SO2CF3 as an amination reagent and FeCl2 as a chloride source. The operationally simple procedure features mild reaction conditions, good functional group compatibility, and high regioselectivity. An example of aminobromination using FeBr2 is also realized. Additionally, a one-pot aminoazidation of styrenes is achieved by adding sodium azide to the reaction. The gram-scale synthesis and downstream derivatization of the products are showcased as well.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2021
Document type:
Article
Affiliation country:
China