A preliminary study of the plasma concentrations of orally administered fluconazole in alpacas (Vicugna pacos).
J Vet Pharmacol Ther
; 45(1): 99-106, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-34165194
ABSTRACT
Alpacas residing in the region endemic for Coccidioides spp. are susceptible to serious, disseminated coccidioidomycosis that may result in death. There is currently no oral antifungal dose recommendation for this species. We used a steady-state study design to assess the pharmacokinetics of oral generic fluconazole in alpacas dosed q 24 h for 14 days. Cohorts of 2-3 animals received fluconazole from 6 to 15 mg/kg/day, and pharmacokinetic analysis was performed after each group of animals in order to make dose adjustments for the next group. The final three animals were used as confirmation of our dose recommendation. The median Tmax was 7 h, and the median Cmax was 1.25 µg/ml per mg/kg dose. The mean dose-normalized 24-h AUC was 41.7 µg h/ml per mg/kg dose (CV = 72%). Based on these results, we recommend alpacas receive a starting dose of oral fluconazole at 10-15 mg/kg/day based on the fluconazole AUC in humans (313-625 µg h/ml). Testing to ascertain putative therapeutic plasma concentrations and monitoring of serum transaminases should be performed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Camelids, New World
/
Fluconazole
Type of study:
Guideline
Limits:
Animals
Language:
En
Journal:
J Vet Pharmacol Ther
Year:
2022
Document type:
Article
Affiliation country:
Estados Unidos