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Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-ß production.
Kao, Yu-Chiu; Chen, Zih-Hua; Wang, Wen-Yu; Lee, Chau-Hwang; Kuo, Po-Ling.
Affiliation
  • Kao YC; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan; Research Center for Applied Sciences, Academia Sinica, Taipei, 11529, Taiwan.
  • Chen ZH; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan.
  • Wang WY; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan.
  • Lee CH; Research Center for Applied Sciences, Academia Sinica, Taipei, 11529, Taiwan; Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan. Electronic address: clee@gate.sinica.edu.tw.
  • Kuo PL; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 10617, Taiwan; Department of Electrical Engineering, National Taiwan University, Taipei, 10617, Taiwan; Department of Rehabilitation, National Taiwan University Hospital, Taipei, 10002, Taiwan. Elect
Biochem Biophys Res Commun ; 568: 15-22, 2021 09 03.
Article in En | MEDLINE | ID: mdl-34174537
ABSTRACT
Fibroblast migration is closely regulated by the mechanical characteristics in surrounding microenvironment. While increased interstitial hydrostatic pressure (HP) is a hallmark in many pathological and physiological conditions, little is known about how the HP affects fibroblast motility. Using cell-culture chips with elevated HP conditions, we showed that 20 cmH2O HP significantly accelerated fibroblast migration. The HP-induced migration acceleration was dependent on the augmentation of transforming growth factor-ß1, and correlated with the activation of filamin A via the phosphorylation of p38 mitogen-activated protein kinase. Our results suggest that interstitial HP elevation associated with various pathological states could significantly regulate fibroblast migration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Transforming Growth Factor beta / P38 Mitogen-Activated Protein Kinases / Fibroblasts / Filamins Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2021 Document type: Article Affiliation country: Taiwán
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Transforming Growth Factor beta / P38 Mitogen-Activated Protein Kinases / Fibroblasts / Filamins Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2021 Document type: Article Affiliation country: Taiwán